Cell sodium-induced recruitment of Na(+)-K(+)-ATPase pumps in rabbit cortical collecting tubules is aldosterone-dependent.
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چکیده
منابع مشابه
The role of Na+-K+-ATPase in the basic and rate-dependent properties of isolated perfused rabbit Atrioventricular Node
Introduction: Ouabaine is a well-known atrioventricular (AV) node depressant agent, but its effects on functional properties of the AV node have not been cleared. The aim of the present study was to determine how ouabaine administration modifies the rate-dependent properties of the AV node. Methods: Selective stimulation protocols were used to quantify independently electrophysiological prop...
متن کاملRegulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K
The patch-clamp technique was used to study the properties and the density of conducting K and Na channels in the apical membrane of rat cortical collecting tubule. The predominant K channel observed in cell-attached patches (SK channels) had an outward single-channel conductance (with LiCl in the pipette) of 10 pS. The inward conductance (with KCl in the pipette) was 42 pS. The channel had a h...
متن کاملCollecting duct (Na+/K+)-ATPase activity is correlated with urinary sodium excretion in rat nephrotic syndromes.
In puromycin aminonucleoside (PAN)-treated nephrotic rats, sodium retention is associated with increased (Na+/K+)-ATPase activity in the cortical collecting ducts (CCD). This study was undertaken to determine whether stimulation of (Na+/K+)-ATPase in the CCD is a feature of other experimental nephrotic syndromes, whether it might be responsible for renal sodium retention, and whether it is medi...
متن کاملH-K-ATPase in the RCCT-28A rabbit cortical collecting duct cell line.
In the present study, we demonstrate that the rabbit cortical collecting duct cell line RCCT-28A possesses three distinct H-K-ATPase catalytic subunits (HKα). Intracellular measurements of RCCT-28A cells using the pH-sensitive dye 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) indicated that the mechanism accounting for recovery from an acid load exhibited both K+ dependence and sens...
متن کاملSecondary effect of aldosterone on Na-KATPase activity in the rabbit cortical collecting tubule.
The possibility that mineralocorticoids have a direct influence on renal Na-K ATPase activity has been the focus of intense research effort and some controversy for a number of years. Early studies were hindered by an inability to differentiate between possible glucocorticoid vs. mineralocorticoid effects on this enzyme within the multitude of cells that comprise the heterogeneous mammalian nep...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1990
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)38450-9